Ospreys know a victory at Ravenhill will allow them to Leapfrog Ulster to the top of the Pro 12.
Unbeaten Cardiff host a free scoring Leinster side in the late kick off on Saturday.
After defeats last time out both Brive and Racing will be hoping to get back to winning ways.
Udinese host a Lazio side that they have only beaten once in their last six meetings.
Both Deportivo and Sporting Gijon will be desperate to end their winless runs when they face of on Saturday.
A victory is the minimum goal for a New Zealand side who have ran away with the Rugby Championship this season.
Can Australia gain revenge and square up the series?
Valencia will do well to maintain their current good form when they host Atletico at the Mestalla stadium on Sunday.
Juventus have won 31 of their last 34 matches in Serie A.
United will be expecting to build on last weeks big win when they host a Stoke side who are winless in the league this season.
Hibs are undefeated in 11 of their last 12 matches in the Scottish Championship.
It's all to play for in this top of the table clash at White Hart Lane on Sunday.
Who will take the spoils in the first International game of the season?